The effect of alanine administration to the treated rats on the enzyme activity was also investigated. We also studied the in vitro effect of the two amino acids on pyruvate kinase activity in the brain cortex of nontreated rats.
The results indicated that tryptophan inhibits pyruvate kinase in vitro and in vivo and that alanine prevents this inhibitory effect on the enzyme activity. Beaudet, W. S, Sly, and D, Valle, eds. Lowry, O. Protein measurement with the Folin phenol reagent. Alanine prevents the in vitro inhibition of glycolysis caused by phenylalanine in brain cortex of rats. Brain Dis. Marsden, D. Anabolic effect of human hormone: Management of inherited disorders of catabolic pathways. Martin, I. Familial hypertryptophanemia in two siblings.
Snedden, W. Familial hypertryptophanemia, tryptophanuria and indolketonuria. Acta Srivastava, L. Purification and properties of rat brain pyruvate kinase. Stone, T. Quinolinic acid and other kynurenines in the central nervous system. Neuroscience 15 Tada, K. Tohoku J. Terlecki, G. Purification and properties of pyruvate kinase M 1 from bovine brain. Vijayvargiya, R.
Pyruvate kinase: Modulation by L-phenylalanine and L-alanine. Download references. You can also search for this author in PubMed Google Scholar. Reprints and Permissions.
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